Tumor Micro-environment

In order to develop novel therapies, research in the lab of Rosalind Segal, MD, PhD is aimed at understanding the biology of cerebellar pilocytic astrocytomas.  Why do tumors that express the KIAA1549-BRAF fusion genes only occur in the cerebellum?  Using a brain slice culture assay, we are currently exploring whether the tumor micro-environment is critical for growth and development.  We are also constructing robust mouse models of disease so we can further study these questions.  In collaboration with Nathanael Gray, PhD and Charles Stiles, PhD we are also using the slice culture assay to test preclinical compounds on their ability to impede tumor growth.

Selected Publications