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Watch Dr. Loren Walensky talk about the collaborative drug discovery taking place at Dana-Farber Cancer Institute

Watch Dr. Loren Walensky talk about the collaborative drug discovery taking place at Dana-Farber Cancer Institute

Loren Walensky, MD, PhD, Associate Professor of Pediatrics, Dana-Farber Cancer Institute and Harvard Medical School, and Principal Investigator, Linde Program in Cancer Chemical Biology, speaks about collaborative drug discovery that is taking place at Dana-Farber Cancer Institute’s Longwood Center.  

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Myxopapillary ependymomas in children: imaging, treatment and outcomes

Myxopapillary ependymomas in children: imaging, treatment and outcomes

In this month’s featured publication, Drs. Ligon, Beroukhim, Kieran and colleagues published a study of the treatment and outcome of children with myxopapillary ependymomas (MPE), a rare spinal tumor.  They examined the diagnosis, imaging, treatment and clinical outcome of eighteen children over a period of 30 years, and found patients with MPE have an excellent […]

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Team Dana-Farber Lab Rats at the 2015 Geared Up for Kids bike ride

Team Dana-Farber Lab Rats at the 2015 Geared Up for Kids bike ride

Team Dana-Farber Lab Rats walked, ran and biked to raise funds for children’s brain tumor research.  Many thanks to Rick Bern for the photograph!

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Genomic Characterization of Brain Metastases Reveals Branched Evolution and Potential Therapeutic Targets.

Genomic Characterization of Brain Metastases Reveals Branched Evolution and Potential Therapeutic Targets.

In this month’s featured publication, Drs. Santagata, Ligon, and Beroukhim and colleagues published a study where they analyzed brain metastases for alterations in their genetic profiles.   In about half of the cases they found different genetic alterations in the brain metastases when compared with the primary tumor site.  This study showed that the genetically […]

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MALDI mass spectrometry imaging analysis of pituitary adenomas for near-real-time tumor delineation

MALDI mass spectrometry imaging analysis of pituitary adenomas for near-real-time tumor delineation

In September’s featured publication, Dr. Nathalie Agar and colleagues show how mass spectrometry imaging can be used to detect pituitary tumors during surgery.  This technology may allow surgeons to characterize between the tumor and healthy tissue border in 30 minutes or less, and can be applied for near-real-time detection and surgical decision-making.

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Future Clinical Trials in DIPG: Bringing Epigenetics to the Clinic.

Future Clinical Trials in DIPG: Bringing Epigenetics to the Clinic.

In August’s featured publication, Dr. Kieran and his collaborators discuss diffuse intrinsic pontine glioma (DIPG), and the role of epigenetic and genetic mutations within these tumors that will allow the development of novel therapies in the future.

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Dr. Walensky received the 2015 E. Mead Johnson Award for Research in Pediatrics

Dr. Walensky received the 2015 E. Mead Johnson Award for Research in Pediatrics

Dr. Walensky is one of two recipients of the 2015 E. Mead Johnson Award for Research in Pediatrics.  This award is given by the American Pediatric Society each year at their annual meeting, and honors outstanding clinical and laboratory research achievements in pediatrics.  To find out more about Dr. Walensky’s research, visit his lab website.  […]

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Pediatric brainstem gliomas: new understanding leads to potential new treatments for two very different tumors.

Pediatric brainstem gliomas: new understanding leads to potential new treatments for two very different tumors.

In this month’s featured publication, Dr. Kieran discusses pediatric brain stem gliomas, and how new biological discoveries may lead to potential treatments for these devastating tumors.

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Molecular typing of Meningiomas by Desorption Electrospray Ionization Mass Spectrometry Imaging for Surgical Decision-Making

Molecular typing of Meningiomas by Desorption Electrospray Ionization Mass Spectrometry Imaging for Surgical Decision-Making

In May’s featured publication, Dr. Agar and colleagues developed tools using mass spectrometry to be used to characterize meningioma tumor from healthy brain tissue during surgery.  These tools could therefore enable surgeons to detect the borders of the tumor better, and remove only the tumor tissue, leaving the healthy brain tissue behind.  These developments could […]

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Expression profiles of 151 pediatric low-grade gliomas reveal molecular differences associated with location and histological subtype

Expression profiles of 151 pediatric low-grade gliomas reveal molecular differences associated with location and histological subtype

In our April featured publication, investigators from our Program and their collaborators analyzed the gene expression profiles of 151 pediatric low-grade glioma samples.  They discovered significant differences associated with the location of the tumor, the appearance of the tumor and BRAF mutation status.  In particular, supratentorial juvenile pilocytic astrocytomas were enriched with genes involved in […]

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