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Team Nathan PMC Riders – Lab Visit and Check Presentation

Team Nathan PMC Riders – Lab Visit and Check Presentation

Team Nathan raised $157,967 riding in the 2018 PMC. They came for a lab visit and check presentation on Feb 13. It was a special evening and awesome opportunity for us to show what we do in the lab.  Two teams, riders and scientists, together are a formidable force in the fight against PLGA!

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Dana-Farber helps “Flip the Switch” with the Pediatric Brain Tumor Foundation

Dana-Farber helps “Flip the Switch” with the Pediatric Brain Tumor Foundation

Dana-Farber’s Susan Chi, MD, Jill MacDonald, RN, BSN, CPON, Mimi Bandopadhayay, PhD, MBBS, and Larisa Condurat, PhD help the Pediatric Brain Tumor Foundation “Flip the Switch” on December 27th to light up the Prudential Center in support of pediatric brain tumor research.

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Roz Segal honored for advancing women’s careers.

We are most honored to announce that our Scientific Director, Rosalind Segal, MD, PhD, has won this year’s Edward J Benz Jr. Award for Advancing the Careers of Women Faculty.  Roz is recognized for going “above and beyond to advance women’s careers,” and for “being a consummate role model.” Congratulations Roz!

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Geared Up for Kids 2018

Geared Up for Kids 2018

Team Lab Rats had so much fun this year and raised some $ too! We can’t wait to bike/run/walk again next year! In the meantime, we’ll be working hard in the lab.  

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Brainstem angiocentric gliomas with MYB-QKI rearrangements.

In this featured publication, Drs. Bandopadhyay and Ligon examine the potential for using the MYB-QKI rearrangement as a diagnostic marker in ambiguous or atypical low-grade glioma cases.

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Characterizing genomic alterations in cancer by complementary functional associations

In this month’s featured publication, Drs. Hahn and Beroukhim and colleagues present REVEALER, a computational tool to investigate the functional consequences of the many mutations identified in tumor samples.  Distinguishing “driver” mutations that underlie oncogenic phenotypes from “passenger” mutations with no evident functional consequences is critical to the development of effective targeted therapies. This publication demonstrates the ability of […]

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DFCI Lab Rats are Geared Up for Kids!

DFCI Lab Rats are Geared Up for Kids!

The DFCI Lab Rats are running, walking and biking at 2018’s Geared Up for Kids!  Please visit our page to join our team and donate!

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Spatial and temporal homogeneity of driver mutations in diffuse intrinsic pontine glioma

Spatial and temporal homogeneity of driver mutations in diffuse intrinsic pontine glioma

In this month’s featured publication, Dr. Ligon and colleagues analyzed 134 diffuse intrinsic pontine glioma (DIPG) samples for their genetic make-up.  They determined that the DIPG tumors are associated with a particular mutation H3K27M, which is the initial driver of tumor formation, and that this mutation is maintained throughout the course of disease.  These findings […]

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Clinical and treatment factors determining long-term outcomes for adult survivors of childhood low-grade glioma: A population-based study.

Clinical and treatment factors determining long-term outcomes for adult survivors of childhood low-grade glioma: A population-based study.

In this month’s Featured Publication, Dr. Kieran and colleagues studied the outcomes of adult survivors of pediatric low-grade glioma over a 27 year span.  They found that overall, patients showed excellent long-term survival, but this was somewhat decreased in patients who had received upfront radiotherapy.  The article suggests that these observations be considered when treatment […]

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MYB-QKI rearrangements in angiocentric glioma drive tumorigenicity through a tripartite mechanism

MYB-QKI rearrangements in angiocentric glioma drive tumorigenicity through a tripartite mechanism

In this month’s featured publication, researchers from the PLGA Program and their collaborators identify a new genetic driver of pediatric angiocentric glioma, called MYB-QKI.  The genetic driver of angiocentric gliomas was previously unknown.  MYB-QKI is an fusion protein that can drive tumor formation by several mechanisms, and its presence in a tumor sample provides an […]

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