MYB-QKI rearrangements in angiocentric glioma drive tumorigenicity through a tripartite mechanism

In this month’s featured publication, researchers from the PLGA Program and their collaborators identify a new genetic driver of pediatric angiocentric glioma, called MYB-QKI.  The genetic driver of angiocentric gliomas was previously unknown.  MYB-QKI is an fusion protein that can drive tumor formation by several mechanisms, and its presence in a tumor sample provides an important diagnostic tool and an avenue for therapy in angiocentric glioma.

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