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MALDI mass spectrometry imaging analysis of pituitary adenomas for near-real-time tumor delineation

MALDI mass spectrometry imaging analysis of pituitary adenomas for near-real-time tumor delineation

In September’s featured publication, Dr. Nathalie Agar and colleagues show how mass spectrometry imaging can be used to detect pituitary tumors during surgery.  This technology may allow surgeons to characterize between the tumor and healthy tissue border in 30 minutes or less, and can be applied for near-real-time detection and surgical decision-making.

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Future Clinical Trials in DIPG: Bringing Epigenetics to the Clinic.

Future Clinical Trials in DIPG: Bringing Epigenetics to the Clinic.

In August’s featured publication, Dr. Kieran and his collaborators discuss diffuse intrinsic pontine glioma (DIPG), and the role of epigenetic and genetic mutations within these tumors that will allow the development of novel therapies in the future.

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Dr. Walensky received the 2015 E. Mead Johnson Award for Research in Pediatrics

Dr. Walensky received the 2015 E. Mead Johnson Award for Research in Pediatrics

Dr. Walensky is one of two recipients of the 2015 E. Mead Johnson Award for Research in Pediatrics.  This award is given by the American Pediatric Society each year at their annual meeting, and honors outstanding clinical and laboratory research achievements in pediatrics.  To find out more about Dr. Walensky’s research, visit his lab website.  […]

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Pediatric brainstem gliomas: new understanding leads to potential new treatments for two very different tumors.

Pediatric brainstem gliomas: new understanding leads to potential new treatments for two very different tumors.

In this month’s featured publication, Dr. Kieran discusses pediatric brain stem gliomas, and how new biological discoveries may lead to potential treatments for these devastating tumors.

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Molecular typing of Meningiomas by Desorption Electrospray Ionization Mass Spectrometry Imaging for Surgical Decision-Making

Molecular typing of Meningiomas by Desorption Electrospray Ionization Mass Spectrometry Imaging for Surgical Decision-Making

In May’s featured publication, Dr. Agar and colleagues developed tools using mass spectrometry to be used to characterize meningioma tumor from healthy brain tissue during surgery.  These tools could therefore enable surgeons to detect the borders of the tumor better, and remove only the tumor tissue, leaving the healthy brain tissue behind.  These developments could […]

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Expression profiles of 151 pediatric low-grade gliomas reveal molecular differences associated with location and histological subtype

Expression profiles of 151 pediatric low-grade gliomas reveal molecular differences associated with location and histological subtype

In our April featured publication, investigators from our Program and their collaborators analyzed the gene expression profiles of 151 pediatric low-grade glioma samples.  They discovered significant differences associated with the location of the tumor, the appearance of the tumor and BRAF mutation status.  In particular, supratentorial juvenile pilocytic astrocytomas were enriched with genes involved in […]

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Dana-Farber Lab Rats are joining Geared Up for Kids 2015!

Dana-Farber Lab Rats are joining Geared Up for Kids 2015!

This year’s Geared Up for Kids 2015 is on June 7th, Cutler Park, Needham.  Registration is now open, please join us either walking, running or biking to fund raise for research into childhood brain tumors, and stick around afterwards for a family fun festival!  To find out more about our team click here.  We hope […]

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BRAF Mutation and CDKN2A Deletion Define a Clinically Distinct Subgroup of Childhood Secondary High-Grade Glioma

BRAF Mutation and CDKN2A Deletion Define a Clinically Distinct Subgroup of Childhood Secondary High-Grade Glioma

In this month’s featured publication, Dr. Ligon and colleagues investigate the genetic changes that lead to the transformation of pediatric low-grade glioma to secondary high-grade glioma. Using advanced sequencing techniques, they analyzed 886 patient samples and showed there were recurrent alterations in BRAF (to BRAFV600E) and deletion of CDKN2A, amongst other changes in tumors that […]

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Discover our breakthroughs against DIPG (Diffuse Intrinsic Pontine Glioma) and AT/RT (Atypical teratoid/rhabdoid tumor)

Discover our breakthroughs against DIPG (Diffuse Intrinsic Pontine Glioma) and AT/RT (Atypical teratoid/rhabdoid tumor)

Dr. Mark Kieran talks about the  discoveries and therapeutic opportunities for children diagnosed with DIPG (Diffuse Intrinsic Pontine Glioma) and AT/RT (Atypical teratoid/rhabdoid tumor) at Dana-Farber Cancer Institute. Treating AT/RT: New Hope for Kids with a rare brain cancer.     New DIPG Advances: Promise for kids with brainstem gliomas

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Why Raising Funds is Critical to Children Battling Brain Tumors

Why Raising Funds is Critical to Children Battling Brain Tumors

Video from our 2015 annual Scientific Advisory Board poster session and family reception featuring Dr. Kieran, Clinical Director.

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