admin

Characterizing genomic alterations in cancer by complementary functional associations

In this month’s featured publication, Drs. Hahn and Beroukhim and colleagues present REVEALER, a computational tool to investigate the functional consequences of the many mutations identified in tumor samples.  Distinguishing “driver” mutations that underlie oncogenic phenotypes from “passenger” mutations with no evident functional consequences is critical to the development of effective targeted therapies. This publication demonstrates the ability of […]

Read More →

Read More →

DFCI Lab Rats are Geared Up for Kids!

DFCI Lab Rats are Geared Up for Kids!

The DFCI Lab Rats are running, walking and biking at 2016’s Geared Up for Kids!  Support our team here!

Read More →

Read More →

Spatial and temporal homogeneity of driver mutations in diffuse intrinsic pontine glioma

Spatial and temporal homogeneity of driver mutations in diffuse intrinsic pontine glioma

In this month’s featured publication, Dr. Ligon and colleagues analyzed 134 diffuse intrinsic pontine glioma (DIPG) samples for their genetic make-up.  They determined that the DIPG tumors are associated with a particular mutation H3K27M, which is the initial driver of tumor formation, and that this mutation is maintained throughout the course of disease.  These findings […]

Read More →

Read More →

Clinical and treatment factors determining long-term outcomes for adult survivors of childhood low-grade glioma: A population-based study.

Clinical and treatment factors determining long-term outcomes for adult survivors of childhood low-grade glioma: A population-based study.

In this month’s Featured Publication, Dr. Kieran and colleagues studied the outcomes of adult survivors of pediatric low-grade glioma over a 27 year span.  They found that overall, patients showed excellent long-term survival, but this was somewhat decreased in patients who had received upfront radiotherapy.  The article suggests that these observations be considered when treatment […]

Read More →

Read More →

MYB-QKI rearrangements in angiocentric glioma drive tumorigenicity through a tripartite mechanism

MYB-QKI rearrangements in angiocentric glioma drive tumorigenicity through a tripartite mechanism

In this month’s featured publication, researchers from the PLGA Program and their collaborators identify a new genetic driver of pediatric angiocentric glioma, called MYB-QKI.  The genetic driver of angiocentric gliomas was previously unknown.  MYB-QKI is an fusion protein that can drive tumor formation by several mechanisms, and its presence in a tumor sample provides an […]

Read More →

Read More →

A Brain Tumor/Organotypic Slice Co-culture System for Studying Tumor Microenvironment and Targeted Drug Therapies.

A Brain Tumor/Organotypic Slice Co-culture System for Studying Tumor Microenvironment and Targeted Drug Therapies.

In this month’s featured publication, Drs. Segal and Stiles describe a new system to culture primary brain tumor types that otherwise prove difficult to propagate.  This culture system enables the team to investigate the role of the tumor microenvironment, and to test potential therapies on tumor cell growth.

Read More →

Read More →

Watch Dr. Loren Walensky talk about the collaborative drug discovery taking place at Dana-Farber Cancer Institute

Watch Dr. Loren Walensky talk about the collaborative drug discovery taking place at Dana-Farber Cancer Institute

Loren Walensky, MD, PhD, Associate Professor of Pediatrics, Dana-Farber Cancer Institute and Harvard Medical School, and Principal Investigator, Linde Program in Cancer Chemical Biology, speaks about collaborative drug discovery that is taking place at Dana-Farber Cancer Institute’s Longwood Center.  

Read More →

Read More →

Myxopapillary ependymomas in children: imaging, treatment and outcomes

Myxopapillary ependymomas in children: imaging, treatment and outcomes

In this month’s featured publication, Drs. Ligon, Beroukhim, Kieran and colleagues published a study of the treatment and outcome of children with myxopapillary ependymomas (MPE), a rare spinal tumor.  They examined the diagnosis, imaging, treatment and clinical outcome of eighteen children over a period of 30 years, and found patients with MPE have an excellent […]

Read More →

Read More →

Team Dana-Farber Lab Rats at the 2015 Geared Up for Kids bike ride

Team Dana-Farber Lab Rats at the 2015 Geared Up for Kids bike ride

Team Dana-Farber Lab Rats walked, ran and biked to raise funds for children’s brain tumor research.  Many thanks to Rick Bern for the photograph!

Read More →

Read More →

Genomic Characterization of Brain Metastases Reveals Branched Evolution and Potential Therapeutic Targets.

Genomic Characterization of Brain Metastases Reveals Branched Evolution and Potential Therapeutic Targets.

In this month’s featured publication, Drs. Santagata, Ligon, and Beroukhim and colleagues published a study where they analyzed brain metastases for alterations in their genetic profiles.   In about half of the cases they found different genetic alterations in the brain metastases when compared with the primary tumor site.  This study showed that the genetically […]

Read More →

Read More →

Top